The production of reactive species is a core of the redox cycling profile of anthracyclines.
However, these molecular characteristics can be viewed as a double‐edged sword acting …

Doxorubicin (DOX) is an anthracycline antibiotic, which is effectively used in the treatment of
different malignancies, such as leukemias and lymphomas. Its most serious side effect is …

Doxorubicin‐(DOX‐) induced cardiotoxicity is associated with oxidative stress and
cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status …

Doxorubicin (DOX) is a highly effective antineoplastic anthracycline drug; however, the
adverse effect of the cardiotoxicity has limited its widespread application. Fibroblast growth …

Doxorubicin is a highly effective, first line chemotherapeutic agent used in the management
of hematological and solid tumors. The effective use of doxorubicin in cancer therapy has …

The clinical usage of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is often
limited by its cardiotoxic effects. Thus, for improving usage of DOX, the aim of this study was …

Flavonoids are considered as pleiotropic, safe, and readily obtainable molecules. A large
number of recent studies have proposed that flavonoids have potential in the treatment of …

Doxorubicin (DOX) is an anthracycline group of antibiotic available for the treatment of broad
spectrum of human cancers. However, patient receiving DOX-therapy, myelosuppression …

Cardiotoxicity limits the clinical applications of doxorubicin (Dox), which mechanism might
be excess generation of intracellular ROS. Quercetin (Que) is a flavonoid that possesses …

Ginger is a medicinal and valuable culinary plant. Gingerols, as an active constituent in the
fresh ginger rhizomes of Zingiber officinale, exhibit several promising pharmacological …