Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions,
and is responsible for increased mortality and poor outcomes in septic patients …

Sepsis is recognized as a life-threatening multi-organ dysfunction resulting from a
dysregulated host response to infection. Although the incidence and mortality of sepsis …

Toll-like receptor 4 (TLR4) sensing of lipopolysaccharide (LPS), the most potent pathogen-
associated molecular pattern of gram-negative bacteria, activates NF-κB and Irf3, which …

Sepsis is a condition of severe organ failure caused by the maladaptive response of the host
to an infection. It is a severe complication affecting critically ill patients, which can progress …

COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory
distress are significant. While a vaccine is in the pipeline, there is urgency for therapeutic …

Sepsis affects millions of people worldwide and is associated with multiorgan dysfunction
that is a major cause of increased morbidity and mortality. Sepsis is associated with several …

Objectives Expound upon priorities for basic/translational science identified in a recent
paper by a group of experts assigned by the Society of Critical Care Medicine and the …

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a redox-sensitive transcription factor that
binds to the antioxidant response element consensus sequence, decreasing reactive …

In Parkinson's disease (PD), brain oxidative stress and mitochondrial dysfunction contribute
to neuronal loss as well as motor and cognitive deficits. The transcription factor NRF2 has …

Sepsis survivors present acute and long-term cognitive impairment and the pathophysiology
of neurological dysfunction in sepsis involves microglial activation. Recently, the …