Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
which responds to anti-inflammatory treatments in the early disease phase. However, the …

Cytotoxic CD8+ T cells are increasingly recognized as key players in various inflammatory
and degenerative central nervous system (CNS) disorders. CD8+ T cells are believed to …

CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with
disease progression, but the pathogenic role and antigenic targets of these clonally …

Background and Purpose—Glucocorticoids potently stabilize the blood–brain barrier and
ameliorate tissue edema in certain neoplastic and inflammatory disorders of the central …

Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing
oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 …

Cytotoxic CD8+ T cells are considered important effector cells contributing to neuronal
damage in inflammatory and degenerative CNS disorders. Using time-lapse video …

Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic
inflammatory demyelination and neurodegeneration in the central nervous system. Although …

Multiple lines of evidence suggest that CD8 T cells contribute to the pathogenesis of multiple
sclerosis (MS). However, the sources and involvement of cytokines such as IL-15 in …

Disruption of the blood brain barrier (BBB) and transendothelial trafficking of immune cells
into the central nervous system (CNS) are pathophysiological hallmarks of Multiple Sclerosis …

Objectives The hallmark histopathology of PM is the presence of CD8+ T cells in the non-
necrotic muscle cells. The aim of this study was to clarify the pathological significance of …