Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

The epithelial–mesenchymal transition (EMT) is a developmental program that enables
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …

Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …

Background During embryonic development, cells often travel long distances to form tissues
and organs. To be able to migrate, embryonic cells undergo a process known as epithelial …

The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of
tissues for which cells originate far from their final destination. Carcinoma cells hijack this …

Abstract Oestrogen receptor-positive (ER+) breast cancer is a major cause of cancer death
in women. Although aromatase inhibitors suppress the function of ER and reduce the risk of …

Primary tumors are known to constantly shed a large number of cancer cells into systemic
dissemination, yet only a tiny fraction of these cells is capable of forming overt metastases …

Pancreatic ductal adenocarcinoma (PDAC) shows pronounced epithelial and mesenchymal
cancer cell populations,,–. Cellular heterogeneity in PDAC is an important feature in disease …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …