Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …

More than 30 years ago, Vincent Allfrey proposed that histone acetylation was associated
with transcriptional activity in eukaryotic cells (Allfrey et al. 1964; Pogo et al. 1966) …

Acetylation of internal lysine residues of core histone N‐terminal domains has been found
correlatively associated with transcriptional activation in eukaryotes for more than three …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

The recruitment model for gene activation stipulates that an activator works by bringing the
transcriptional machinery to the DNA. Recent experiments in bacteria and yeast indicate that …

The general transcription factors of RNA polymerase II. Publisher Logo Genes &
Development Skip to main page content HOME ABOUT SUBMIT SUBSCRIBE ADVERTISE …

TFIID and SAGA share a common set of TAFs, regulate chromatin, and deliver TBP to
promoters. Here we examine their relationship within the context of the Saccharomyces …

). The TBP subunit specifically recognizes TATA elements, which are found in most
eukaryotic promoters, and TFIIB, the protein primarily responsible for connecting TFIID to the …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …