Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

Chalcone synthase and its functions in plant resistance

TTH Dao, HJM Linthorst, R Verpoorte - Phytochemistry Reviews, 2011 - Springer
Abstract Chalcone synthase (CHS, EC 2.3. 1.74) is a key enzyme of the
flavonoid/isoflavonoid biosynthesis pathway. Besides being part of the plant developmental …

Polyketide biosynthesis: a millennium review

J Staunton, KJ Weissman - Natural product reports, 2001 - pubs.rsc.org
Polyketide biosynthesis: a millennium review - Natural Product Reports (RSC Publishing)
DOI:10.1039/A909079G Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article …

A review of anti-infective and anti-inflammatory chalcones

Z Nowakowska - European journal of medicinal chemistry, 2007 - Elsevier
Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in
edible plants, and have also been shown to display a diverse array of pharmacological …

The chalcone synthase superfamily of type III polyketide synthases

MB Austin, JP Noel - Natural product reports, 2003 - pubs.rsc.org
Covering 1970–2001This review covers the functionally diverse type III polyketide synthase
(PKS) superfamily of plant and bacterial biosynthetic enzymes, from the discovery of …

Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review

HL Qin, ZW Zhang, R Lekkala, H Alsulami… - European journal of …, 2020 - Elsevier
Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

HEMOGLOBIN METABOLISM IN THE MALARIA PARASITE PLASMODIUM FALCIPARUM

SE Francis, DJ Sullivan Jr… - Annual Reviews in …, 1997 - annualreviews.org
▪ Abstract Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process
that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic …

Cysteine proteases and their inhibitors

HH Otto, T Schirmeister - Chemical reviews, 1997 - ACS Publications
The large family of peptide-bond-cleaving hydrolases, the peptidases () proteases, EC 3.4),
can be categorized as endopeptidases () proteinases, EC 3.4. 21-99) and exopeptidases …

Chalcones: an update on cytotoxic and chemoprotective properties

ML Go, X Wu, XL Liu - Current medicinal chemistry, 2005 - ingentaconnect.com
Chalcone is a unique template that is associated with several biological activities. In this
review, an update of the cytotoxic and chemoprotective activities of chalcones is provided …