Neural tube defects are severe congenital malformations affecting around one in every 1000
pregnancies. An innovation in clinical management has come from the finding that closure of …

Neural tube defects (NTDs) are the second most common congenital malformations in
humans affecting the development of the central nervous system. Although NTD …

Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord
involvement. The most clinically significant subtype is myelomeningocele (open spina …

This text is intended for those who wish to understand the complex relationships between
diet and risks of important diseases, such as cancer and cardiovascular disease. It is aimed …

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this
review paper is to show the characteristics of common and severe neural-tube defects …

▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …

Recently, we showed that homozygosity for the common 677 (C→ T) mutation in the
methylenetetrahydrofolate reductase (MTHFR) gene, causing thermolability of the enzyme …

Vitamin B12 is essential for DNA synthesis and for cellular energy production. This review
aims to outline the metabolism of vitamin B12, and to evaluate the causes and …

Neural tube defects (NTDs) are common complex congenital malformations resulting from
failure of the neural tube closure during embryogenesis. It is established that folic acid …

Each year spina bifida and anencephaly, the two most common forms of neural-tube defects,
occur in 1 in 1000 pregnancies in the United States1 and an estimated 300,000 or more …