Non-steroidal anti-inflammatory drugs: Recent advances in the use of synthetic COX-2 inhibitors
M Ahmadi, S Bekeschus, KD Weltmann… - RSC Medicinal …, 2022 - pubs.rsc.org
Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities
Hybridization is the process of fusion of two or more existing moieties to make a single
molecule. Triazoles and benzenesulfonamides are the useful pharmacological agents …
molecule. Triazoles and benzenesulfonamides are the useful pharmacological agents …
New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAFV600E and EGFR inhibitors celecoxib …
A new series of bis-triazole 19a-l was synthesised for the purpose of being hybrid molecules
with both anti-inflammatory and anti-cancer activities and assessed for cell cycle arrest, NO …
with both anti-inflammatory and anti-cancer activities and assessed for cell cycle arrest, NO …
Drug discovery of new anti-inflammatory compounds by targeting cyclooxygenases
S Burayk, K Oh-Hashi, M Kandeel - Pharmaceuticals, 2022 - mdpi.com
The goal of achieving anti-inflammatory efficacy with the fewest possible adverse effects
through selective COX-2 inhibition is still being investigated in order to develop drugs with …
through selective COX-2 inhibition is still being investigated in order to develop drugs with …
Microwave-assisted synthesis of novel sulfonamide-based compounds bearing α-aminophosphonate and their antimicrobial properties
E Sabry, HA Mohamed, EF Ewies, BM Kariuki… - Journal of Molecular …, 2022 - Elsevier
A series of α-aminophosphonates (3a-3m) bearing the sulfisoxazole moiety was synthesized
through one-pot Kabachnik-Fields reaction of sulfisoxazole, diethyl phosphite (DEP) and …
through one-pot Kabachnik-Fields reaction of sulfisoxazole, diethyl phosphite (DEP) and …
Click chemistry‐based synthesis of new benzenesulfonamide derivatives bearing triazole ring as selective carbonic anhydrase II inhibitors
EF Ewies, E Sabry, MS Bekheit… - Drug Development …, 2022 - Wiley Online Library
Abstract A series of 1, 2, 3‐triazol‐1‐ylbenzenesulfonamide derivatives was designed,
synthesized and their ability to inhibit several carbonic anhydrase isoforms was evaluated …
synthesized and their ability to inhibit several carbonic anhydrase isoforms was evaluated …
[HTML][HTML] Novel N-(4-thiocyanatophenyl)-1H-1, 2, 3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells
N Pokhodylo, N Finiuk, O Klyuchivska… - European Journal of …, 2022 - Elsevier
Abstract The N-(4-thiocyanatophenyl)-1H-1, 2, 3-triazole-4-carboxamides were synthesized
via the condensation of variety of 1H-1, 2, 3-triazole-4-carboxylic acids and 4 …
via the condensation of variety of 1H-1, 2, 3-triazole-4-carboxylic acids and 4 …
Design of new hybrids indole/phthalimide/oxadiazole-1, 2, 3 triazole agents and their anticancer properties
HA Mohamed, MS Bekheit, EF Ewies, HM Awad… - Journal of Molecular …, 2023 - Elsevier
A series of a new hybrid compounds combining 1, 2, 3-triazole with oxadiazolyl, Phthalimidyl
or indolyl moiety has been synthesized. The reaction of our starting compound 5-phenyl-1 …
or indolyl moiety has been synthesized. The reaction of our starting compound 5-phenyl-1 …
Design, Synthesis, In vitro and In vivo Evaluation of New Imidazo [1, 2-a] pyridine Derivatives as Cyclooxygenase-2 Inhibitors
N Ahmadi, M Khoramjouy… - Anti-Cancer Agents …, 2024 - ingentaconnect.com
Background: Cyclooxygenase-2 (COX-2), the key enzyme in the arachidonic acid
conversion to prostaglandins, is one of the enzymes associated with different …
conversion to prostaglandins, is one of the enzymes associated with different …
Countenance and implication of Β-sitosterol, Β-amyrin and epiafzelechin in nickel exposed Rat: in-silico and in-vivo approach
The detrimental impact of reactive oxygen species on DNA repair processes is one of the
contributing factors to colon cancer. The idea that oxidative stress may be a significant …
contributing factors to colon cancer. The idea that oxidative stress may be a significant …