[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

L Zhang, K Hu, T Shao, L Hou, S Zhang, W Ye… - … Pharmaceutica Sinica B, 2021 - Elsevier
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Fluorine-18 labelled building blocks for PET tracer synthesis

D Van Der Born, A Pees, AJ Poot, RVA Orru… - Chemical Society …, 2017 - pubs.rsc.org
Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases

MM Alam, J Lee, SY Lee - Nuclear medicine and molecular imaging, 2017 - Springer
Neuroinflammation is heavily associated with various neurological diseases including
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …

The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing

P Singh, A Adhikari, D Singh, C Gond, AK Tiwari - ACS omega, 2022 - ACS Publications
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …

18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study

TG Luu, HK Kim - Pharmaceutics, 2022 - mdpi.com
Translocator protein 18 kDa (TSPO) is a transmembrane protein in the mitochondrial
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …

An update into the medicinal chemistry of translocator protein (TSPO) ligands

E Barresi, M Robello, B Costa, E Da Pozzo… - European Journal of …, 2021 - Elsevier
Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …

[HTML][HTML] Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography

B Janssen, DJ Vugts, U Funke, GT Molenaar… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …

[HTML][HTML] Essential principles and recent progress in the development of TSPO PET ligands for neuroinflammation imaging

M Viviano, E Barresi, FG Siméon, B Costa… - Current medicinal …, 2022 - ncbi.nlm.nih.gov
The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis …

Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats

T Keller, A Krzyczmonik, S Forsback, FRL Picón… - Molecular Imaging and …, 2017 - Springer
Purpose Many neurological conditions result in the overexpression of the translocator
protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and …

[HTML][HTML] [18F] FEBMP: positron emission tomography imaging of TSPO in a model of neuroinflammation in rats, and in vitro autoradiograms of the human brain

AK Tiwari, B Ji, J Yui, M Fujinaga, T Yamasaki, L Xie… - Theranostics, 2015 - ncbi.nlm.nih.gov
We evaluated the efficacy of 2-[5-(4-[18 F] fluoroethoxy-2-oxo-1, 3-benzoxazol-3 (2H)-yl)-N-
methyl-N-phenylacetamide]([18 F] FEBMP) for positron emission tomography (PET) imaging …