[HTML][HTML] Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …
Fluorine-18 labelled building blocks for PET tracer synthesis
D Van Der Born, A Pees, AJ Poot, RVA Orru… - Chemical Society …, 2017 - pubs.rsc.org
Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …
Recent progress in the development of TSPO PET ligands for neuroinflammation imaging in neurological diseases
MM Alam, J Lee, SY Lee - Nuclear medicine and molecular imaging, 2017 - Springer
Neuroinflammation is heavily associated with various neurological diseases including
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly …
The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …
169-amino-acid protein which localizes on the contact sites between the outer and inner …
18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
Translocator protein 18 kDa (TSPO) is a transmembrane protein in the mitochondrial
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
membrane, which has been identified as a peripheral benzodiazepine receptor. TSPO is …
An update into the medicinal chemistry of translocator protein (TSPO) ligands
E Barresi, M Robello, B Costa, E Da Pozzo… - European Journal of …, 2021 - Elsevier
Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …
[HTML][HTML] Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography
B Janssen, DJ Vugts, U Funke, GT Molenaar… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain,
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
including Alzheimer's disease, multiple sclerosis and stroke. Neuroinflammation is …
[HTML][HTML] Essential principles and recent progress in the development of TSPO PET ligands for neuroinflammation imaging
M Viviano, E Barresi, FG Siméon, B Costa… - Current medicinal …, 2022 - ncbi.nlm.nih.gov
The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis …
and is implicated in several functions, including cholesterol transport and steroidogenesis …
Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats
T Keller, A Krzyczmonik, S Forsback, FRL Picón… - Molecular Imaging and …, 2017 - Springer
Purpose Many neurological conditions result in the overexpression of the translocator
protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and …
protein 18 kDa (TSPO), today recognized as a biomarker for microglial activation and …
[HTML][HTML] [18F] FEBMP: positron emission tomography imaging of TSPO in a model of neuroinflammation in rats, and in vitro autoradiograms of the human brain
AK Tiwari, B Ji, J Yui, M Fujinaga, T Yamasaki, L Xie… - Theranostics, 2015 - ncbi.nlm.nih.gov
We evaluated the efficacy of 2-[5-(4-[18 F] fluoroethoxy-2-oxo-1, 3-benzoxazol-3 (2H)-yl)-N-
methyl-N-phenylacetamide]([18 F] FEBMP) for positron emission tomography (PET) imaging …
methyl-N-phenylacetamide]([18 F] FEBMP) for positron emission tomography (PET) imaging …