Biomedicine represents one of the main study areas for dendrimers, which have proven to
be valuable both in diagnostics and therapy, due to their capacity for improving solubility …

Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

Dendrimers are discrete nanostructures/nanoparticles with 'onion skin‐like'branched layers.
Beginning with a core, these nanostructures grow in concentric layers to produce stepwise …

Abstract Poly (amidoamine)(PAMAM) dendrimers are well-defined, highly branched
macromolecules with numerous active amine groups on the surface. Because of their …

1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers
are already successfully used in experimental gene therapies, but despite advantages such …

Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

Neuroinflammation, mediated by activated microglia and astrocytes, plays a key role in the
pathogenesis of many neurological disorders. Systemically-administered dendrimers target …

One of the unmet challenges in nanotechnology is to understand and establish the
relationship between physicochemical properties of nanoparticles (NPs) and its biological …

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …