Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many
cell types into the extracellular milieu. They correspond to the internal vesicles of an …

Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …

The sorting of transmembrane proteins (eg, cell surface receptors) into the multivesicular
body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Sorting of ubiquitinated endosomal membrane proteins into the MVB pathway is executed
by the class E Vps protein complexes ESCRT-I,-II, and-III, and the AAA-type ATPase Vps4 …

The major cellular pathways for protein and organelle turnover are autophagy and
proteasome-mediated degradation. These processes are important to maintain a well …

Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within …

Ubiquitination appears to be involved in virus particle release from infected cells. Free
ubiquitin (Ub), as well as Ub covalently bound to a small fraction of p6 Gag, is detected in …

Abstract Background: Sorting nexins (SNXs) are phox homology (PX) domain-containing
proteins thought to regulate endosomal sorting of internalized receptors. The prototypical …