The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
JR Inigo, D Chandra - Journal of hematology & oncology, 2022 - Springer
Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …
The biogenesis and functions of exosomes
W Stoorvogel, MJ Kleijmeer, HJ Geuze, G Raposo - Traffic, 2002 - Wiley Online Library
Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many
cell types into the extracellular milieu. They correspond to the internal vesicles of an …
cell types into the extracellular milieu. They correspond to the internal vesicles of an …
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
JE Garrus, UK von Schwedler, OW Pornillos… - Cell, 2001 - cell.com
Like other enveloped viruses, HIV-1 uses cellular machinery to bud from infected cells. We
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …
now show that Tsg101 protein, which functions in vacuolar protein sorting (Vps), is required …
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting
M Babst, DJ Katzmann, EJ Estepa-Sabal, T Meerloo… - Developmental cell, 2002 - cell.com
The sorting of transmembrane proteins (eg, cell surface receptors) into the multivesicular
body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT …
body (MVB) pathway to the lysosomal/vacuolar lumen requires the function of the ESCRT …
Phagosome maturation: aging gracefully
Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …
leucocytes. The initial stage of the elimination process is the internalization of the particles …
Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body
M Babst, DJ Katzmann, WB Snyder, B Wendland… - Developmental cell, 2002 - cell.com
Sorting of ubiquitinated endosomal membrane proteins into the MVB pathway is executed
by the class E Vps protein complexes ESCRT-I,-II, and-III, and the AAA-type ATPase Vps4 …
by the class E Vps protein complexes ESCRT-I,-II, and-III, and the AAA-type ATPase Vps4 …
Autophagy in the eukaryotic cell
F Reggiori, DJ Klionsky - Eukaryotic cell, 2002 - Am Soc Microbiol
The major cellular pathways for protein and organelle turnover are autophagy and
proteasome-mediated degradation. These processes are important to maintain a well …
proteasome-mediated degradation. These processes are important to maintain a well …
The endocytic pathway: a mosaic of domains
J Gruenberg - Nature reviews Molecular cell biology, 2001 - nature.com
Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within …
regions. These regions consist, at least in part, of specialized protein–lipid domains within …
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55Gag
L VerPlank, F Bouamr, TJ LaGrassa… - Proceedings of the …, 2001 - National Acad Sciences
Ubiquitination appears to be involved in virus particle release from infected cells. Free
ubiquitin (Ub), as well as Ub covalently bound to a small fraction of p6 Gag, is detected in …
ubiquitin (Ub), as well as Ub covalently bound to a small fraction of p6 Gag, is detected in …
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides
Abstract Background: Sorting nexins (SNXs) are phox homology (PX) domain-containing
proteins thought to regulate endosomal sorting of internalized receptors. The prototypical …
proteins thought to regulate endosomal sorting of internalized receptors. The prototypical …