GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …
whose expression is increased in response to cellular stress and disease as well as by …
[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …
valuable method for identifying elderly people at risk for increased vulnerability, disease …
The GDF15-GFRAL pathway in health and metabolic disease: friend or foe?
GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …
[HTML][HTML] Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight
Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …
Identification of biomarkers for glycaemic deterioration in type 2 diabetes
RC Slieker, LA Donnelly, E Akalestou… - Nature …, 2023 - nature.com
We identify biomarkers for disease progression in three type 2 diabetes cohorts
encompassing 2,973 individuals across three molecular classes, metabolites, lipids and …
encompassing 2,973 individuals across three molecular classes, metabolites, lipids and …
Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
Type 2 diabetes mellitus (T2DM) is a chronic endocrine disorder due to the reduction of
insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 …
insulin sensitivity and relative deficiency of insulin secretion. Growth differentiation factor 15 …
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat …
GDF15 deficiency exacerbates chronic alcohol-and carbon tetrachloride-induced liver injury
Abstract Growth differentiation factor 15 (GDF15) has recently been shown to have an
important role in the regulation of mitochondrial function and in the pathogenesis of complex …
important role in the regulation of mitochondrial function and in the pathogenesis of complex …
Growth differentiation factor 15: A novel biomarker with high clinical potential
S Desmedt, V Desmedt, L De Vos… - Critical Reviews in …, 2019 - Taylor & Francis
Initially considered as a macrophage inhibitor (macrophage inhibitory cytokine-1), growth
differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key …
differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key …
The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
Mitochondria perform essential roles as crucial organelles for cellular and systemic energy
homeostasis, and as signaling hubs, which coordinate nuclear transcriptional responses to …
homeostasis, and as signaling hubs, which coordinate nuclear transcriptional responses to …