Neurodegenerative diseases (NDs) are characterized by the aggregation of neurotoxic
proteins in the central nervous system. Aberrant protein accumulation in NDs is largely …

Many pathways important to the nervous system are regulated by the post-translational
conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination …

Although the causes of Parkinson's disease (PD) are thought to be primarily environmental,
recent studies suggest that a number of genes influence susceptibility. Using targeted case …

Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative
prevalence of greater than one per thousand. To date three independent genome‐wide …

miRNAs were recently implicated in the pathogenesis of numerous diseases, including
neurological disorders such as Parkinson's disease (PD). miRNAs are abundant in the …

MicroRNAs (miRNAs) are highly conserved non-coding RNAs modulating gene expression
via mRNA binding. Recent work suggests an involvement of miRNAs in cardiovascular …

Vitamin D and vitamin D receptor (VDR) have been postulated as environmental and
genetic factors in neurodegeneration disorders including multiple sclerosis (MS), Alzheimer …

The identification of single genes and their functional characterization has enhanced our
understanding of the pathogenesis of parkinsonism, has led to improvement of diagnostic …

Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder, characterized
by the misfolding and aggregation of α-synuclein (α-syn) into Lewy bodies and the …

Abstract Background Short tandem repeats (STRs) compose approximately 3% of the
genome, and mutations at STR loci have been linked to dozens of human diseases …