Diverse and unified mechanisms of transcription initiation in bacteria
Transcription of DNA is a fundamental process in all cellular organisms. The enzyme
responsible for transcription, RNA polymerase, is conserved in general architecture and …
responsible for transcription, RNA polymerase, is conserved in general architecture and …
Bacterial transcription as a target for antibacterial drug development
Transcription, the first step of gene expression, is carried out by the enzyme RNA
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …
polymerase (RNAP) and is regulated through interaction with a series of protein transcription …
Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA
Chemical modification of transcripts with 5′ caps occurs in all organisms. Here, we report a
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an …
The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA
The chemical nature of the 5′ end of RNA is a key determinant of RNA stability, processing,
localization and translation efficiency,, and has been proposed to provide a layer of …
localization and translation efficiency,, and has been proposed to provide a layer of …
[HTML][HTML] Crystal structures of the E. coli transcription initiation complexes with a complete bubble
Y Zuo, TA Steitz - Molecular cell, 2015 - cell.com
During transcription initiation, RNA polymerase binds to promoter DNA to form an initiation
complex containing a DNA bubble and enters into abortive cycles of RNA synthesis before …
complex containing a DNA bubble and enters into abortive cycles of RNA synthesis before …
Structural basis of Mycobacterium tuberculosis transcription and transcription inhibition
W Lin, S Mandal, D Degen, Y Liu, YW Ebright, S Li… - Molecular cell, 2017 - cell.com
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, which kills 1.8
million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis …
million annually. Mtb RNA polymerase (RNAP) is the target of the first-line antituberculosis …
[HTML][HTML] Antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase
Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …
Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme
RS Basu, BA Warner, V Molodtsov, D Pupov… - Journal of Biological …, 2014 - ASBMB
The bacterial RNA polymerase (RNAP) holoenzyme containing σ factor initiates transcription
at specific promoter sites by de novo RNA priming, the first step of RNA synthesis where …
at specific promoter sites by de novo RNA priming, the first step of RNA synthesis where …
[HTML][HTML] Recent trends in cyclic peptides as therapeutic agents and biochemical tools
JS Choi, SH Joo - Biomolecules & therapeutics, 2020 - ncbi.nlm.nih.gov
Notable progress has been made in the therapeutic and research applications of cyclic
peptides since our previous review. New drugs based on cyclic peptides are entering the …
peptides since our previous review. New drugs based on cyclic peptides are entering the …
Structural biology of bacterial RNA polymerase
KS Murakami - Biomolecules, 2015 - mdpi.com
Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA
polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical …
polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical …