Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73
pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect …

Ectonucleotidases modulate inflammatory responses by balancing extracellular ATP and
adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we …

The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus
disease 2019 (COVID‐19) pandemic, has spread worldwide since it was first identified in …

Background Several risk factors have been involved in the poor clinical progression of
coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may …

Severe COVID-19 in children is rare, but the reasons underlying are unclear. Profound
alterations in T cell responses have been well characterized in the course of adult severe …

Viral infections trigger inflammation by controlling ATP release. CD39 ectoenzymes
hydrolyze ATP/ADP to AMP, which is converted by CD73 into anti-inflammatory adenosine …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global health concern. Three years …

The pathogenesis of coronavirus disease (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‑CoV‑2), is complex and involves dysregulated immune …

The human respiratory and circulatory systems collaborate intricately to ensure oxygen
delivery to all cells, which is vital for ATP production and maintaining physiological functions …