Hepatic inflammatory responses in liver fibrosis

L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Immune cell-mediated features of non-alcoholic steatohepatitis

T Huby, EL Gautier - Nature reviews immunology, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

F Tacke, T Puengel, R Loomba, SL Friedman - Journal of Hepatology, 2023 - Elsevier
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …

Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities

Y Wen, J Lambrecht, C Ju, F Tacke - Cellular & molecular immunology, 2021 - nature.com
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …

Mechanisms of fibrosis development in nonalcoholic steatohepatitis

RF Schwabe, I Tabas, UB Pajvani - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …

A new era of macrophage-based cell therapy

YR Na, SW Kim, SH Seok - Experimental & Molecular Medicine, 2023 - nature.com
Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …

Hepatic macrophages: Key players in the development and progression of liver fibrosis

D Cheng, J Chai, H Wang, L Fu, S Peng… - Liver …, 2021 - Wiley Online Library
Hepatic fibrosis is a common pathological process involving persistent liver injury with
various etiologies and subsequent inflammatory responses that occur in chronic liver …

Treating inflammation to combat non-alcoholic fatty liver disease

L Wiering, F Tacke - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Non-alcoholic fatty liver disease (NAFLD) with its more progressive form non-alcoholic
steatohepatitis (NASH) has become the most common chronic liver disease, thereby …

Fibrosis regression after eradication of hepatitis C virus: from bench to bedside

DC Rockey, SL Friedman - Gastroenterology, 2021 - Elsevier
Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …