Evolution of phage display libraries for therapeutic antibody discovery
Y Zhang - MAbs, 2023 - Taylor & Francis
Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most
important classes of biotherapeutics in recent decades. The success of mAb is due to their …
important classes of biotherapeutics in recent decades. The success of mAb is due to their …
Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples
M Forinová, A Pilipenco, I Visova… - … applied materials & …, 2021 - ACS Publications
New analytical techniques that overcome major drawbacks of current routinely used viral
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …
[PDF][PDF] Leveraging monoclonal antibodies as therapeutics to address antimicrobial resistance in bacteria
V Verma - Journal of Applied Biology and Biotechnology, 2023 - researchgate.net
Over the past two decades, several technologies have become available to rapidly develop
therapeutic monoclonal antibodies (MAbs) against any target of interest. Consequently …
therapeutic monoclonal antibodies (MAbs) against any target of interest. Consequently …
Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous
environment, where interfacial waters are an integral part of the antibody–protein complex …
environment, where interfacial waters are an integral part of the antibody–protein complex …
Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic …
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and
hence there are increasing needs to develop MSLN-targeting strategies for cancer …
hence there are increasing needs to develop MSLN-targeting strategies for cancer …
Prediction of Paratope–Epitope Pairs Using Convolutional Neural Networks
Antibodies play a central role in the adaptive immune response of vertebrates through the
specific recognition of exogenous or endogenous antigens. The rational design of …
specific recognition of exogenous or endogenous antigens. The rational design of …
Generation of synthetic antibody fragments with optimal complementarity determining region lengths for Notch-1 recognition
BV Maruthachalam, K Barreto, D Hogan… - Frontiers in …, 2022 - frontiersin.org
Synthetic antibodies have been engineered against a wide variety of antigens with desirable
biophysical, biochemical, and pharmacological properties. Here, we describe the generation …
biophysical, biochemical, and pharmacological properties. Here, we describe the generation …
A panel of anti-influenza virus nucleoprotein antibodies selected from phage-displayed synthetic antibody libraries with rapid diagnostic capability to distinguish …
Immunoassays based on sandwich immuno-complexes of capture and detection antibodies
simultaneously binding to the target analytes have been powerful technologies in molecular …
simultaneously binding to the target analytes have been powerful technologies in molecular …
Significance of antibody numbering systems in the development of antibody engineering
R Patel, P Verma, AK Nagraj, A Gavade… - Hum …, 2023 - content.iospress.com
Immunotherapy has become increasingly popular in recent years for treating a variety of
diseases including inflammatory, neurological, oncological, and auto-immune disorders …
diseases including inflammatory, neurological, oncological, and auto-immune disorders …
A novel synthetic antibody Library with complementarity-determining region diversities designed for an improved amplification profile
X Bai, M Jang, NJ Lee, TTH Nguyen, M Jung… - International Journal of …, 2022 - mdpi.com
Antibody discovery by phage display consists of two phases, ie, the binding phase and the
amplification phase. Ideally, the selection process is dominated by the former, and all the …
amplification phase. Ideally, the selection process is dominated by the former, and all the …