Evolution of phage display libraries for therapeutic antibody discovery

Y Zhang - MAbs, 2023 - Taylor & Francis
Monoclonal antibodies (mAbs) and their derivatives have emerged as one of the most
important classes of biotherapeutics in recent decades. The success of mAb is due to their …

Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples

M Forinová, A Pilipenco, I Visova… - … applied materials & …, 2021 - ACS Publications
New analytical techniques that overcome major drawbacks of current routinely used viral
infection diagnosis methods, ie, the long analysis time and laboriousness of real-time …

[PDF][PDF] Leveraging monoclonal antibodies as therapeutics to address antimicrobial resistance in bacteria

V Verma - Journal of Applied Biology and Biotechnology, 2023 - researchgate.net
Over the past two decades, several technologies have become available to rapidly develop
therapeutic monoclonal antibodies (MAbs) against any target of interest. Consequently …

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

HP Peng, HJ Hsu, CM Yu, FH Hung, CP Tung… - Scientific Reports, 2022 - nature.com
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous
environment, where interfacial waters are an integral part of the antibody–protein complex …

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic …

HJ Hsu, CP Tung, CM Yu, CY Chen, HS Chen… - Scientific Reports, 2021 - nature.com
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and
hence there are increasing needs to develop MSLN-targeting strategies for cancer …

Prediction of Paratope–Epitope Pairs Using Convolutional Neural Networks

D Li, F Pucci, M Rooman - International Journal of Molecular Sciences, 2024 - mdpi.com
Antibodies play a central role in the adaptive immune response of vertebrates through the
specific recognition of exogenous or endogenous antigens. The rational design of …

Generation of synthetic antibody fragments with optimal complementarity determining region lengths for Notch-1 recognition

BV Maruthachalam, K Barreto, D Hogan… - Frontiers in …, 2022 - frontiersin.org
Synthetic antibodies have been engineered against a wide variety of antigens with desirable
biophysical, biochemical, and pharmacological properties. Here, we describe the generation …

A panel of anti-influenza virus nucleoprotein antibodies selected from phage-displayed synthetic antibody libraries with rapid diagnostic capability to distinguish …

CM Yu, IC Chen, CP Tung, HP Peng, JW Jian… - Scientific Reports, 2020 - nature.com
Immunoassays based on sandwich immuno-complexes of capture and detection antibodies
simultaneously binding to the target analytes have been powerful technologies in molecular …

Significance of antibody numbering systems in the development of antibody engineering

R Patel, P Verma, AK Nagraj, A Gavade… - Hum …, 2023 - content.iospress.com
Immunotherapy has become increasingly popular in recent years for treating a variety of
diseases including inflammatory, neurological, oncological, and auto-immune disorders …

A novel synthetic antibody Library with complementarity-determining region diversities designed for an improved amplification profile

X Bai, M Jang, NJ Lee, TTH Nguyen, M Jung… - International Journal of …, 2022 - mdpi.com
Antibody discovery by phage display consists of two phases, ie, the binding phase and the
amplification phase. Ideally, the selection process is dominated by the former, and all the …