Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β
family (TGFβ), which signal through hetero-tetrameric complexes of type I and type II …

Extracellular signaling molecules have crucial roles in development and homeostasis, and
their incorrect deployment can lead to developmental defects and disease states. Signaling …

Many patterns of cell and tissue organization are specified during development by gradients
of morphogens, substances that assign different cell fates at different concentrations …

Abstract Jobling, MF, Mott, JD, Finnegan, MT, Jurukovski, V., Erickson, AC, Walian, PJ,
Taylor, SE, Ledbetter, S., Lawrence, CM, Rifkin, DB and Barcellos-Hoff, MH Isoform-Specific …

Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by
signaling through two pairs of structurally related type I and type II receptors. Here we report …

Both latent transforming growth factor-β (TGF-β)-binding proteins fibrillins are components of
microfibril networks, and both interact with members of the TGF-β family of growth factors …

The specific functions of the prodomains of TGFβ superfamily members are largely
unknown. Interactions are known between prodomains of TGFβ-1–3 and latent TGFβ …

The bone morphogenetic protein (BMP) family, the largest subfamily of the structurally
conserved transforming growth factor-β (TGF-β) superfamily of growth factors, are …

TGF-β family ligands are translated as prepropeptide precursors and are processed into
mature C-terminal dimers that signal by assembling a serine/threonine kinase receptor …

Biochemical and biophysical methods are used to show that BMP-7 is secreted as a stable
complex consisting of the processed growth factor dimer noncovalently associated with its …