Evaluation of substituted pyrazole-based kinase inhibitors in one decade (2011–2020): Current status and future prospects
Pyrazole has been recognized as a pharmacologically important privileged scaffold whose
derivatives produce almost all types of pharmacological activities and have attracted much …
derivatives produce almost all types of pharmacological activities and have attracted much …
Recent progress of benzimidazole hybrids for anticancer potential
This review presents the detailed account of factors leading to cancer and design strategy
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …
A Comprehensive In Silico Exploration of Pharmacological Properties, Bioactivities, Molecular Docking, and Anticancer Potential of Vieloplain F from Xylopia vielana …
Compounds derived from plants have several anticancer properties. In the current study,
one guaiane-type sesquiterpene dimer, vieloplain F, isolated from Xylopia vielana species …
one guaiane-type sesquiterpene dimer, vieloplain F, isolated from Xylopia vielana species …
[HTML][HTML] Identification of benzothiazoles bearing 1, 3, 4-thiadiazole as antiproliferative hybrids targeting VEGFR-2 and BRAF kinase: design, synthesis, BIO evaluation …
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled
growth in various organs. Protein kinase inhibitors represent an important class of targeted …
growth in various organs. Protein kinase inhibitors represent an important class of targeted …
Computational exploration of anti-cancer potential of guaiane dimers from Xylopia vielana by targeting B-RAF kinase using chemo-informatics, molecular docking, and …
S Shams ul Hassan, SQ Abbas… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Background: Natural products from herbs are abundant and display powerful anti-cancer
activities. Objectives: In the current study, B-Raf kinase protein (PDB: 3OG7), a potent target …
activities. Objectives: In the current study, B-Raf kinase protein (PDB: 3OG7), a potent target …
[HTML][HTML] Virtual screening, pharmacokinetic, and DFT studies of anticancer compounds as potential V600E-BRAF kinase inhibitors
MAPK signaling is a key regulator of fundamental cellular processes such as growth,
proliferation, differentiation, migration, and apoptosis. 1, 2 Signal transmission is enabled by …
proliferation, differentiation, migration, and apoptosis. 1, 2 Signal transmission is enabled by …
Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma
F Chen, Y Fang, R Zhao, J Le, B Zhang… - European Journal of …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …
Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4 (3H) quinazolinone analogues
IA Al-Suwaidan, AAM Abdel-Aziz… - Journal of enzyme …, 2016 - Taylor & Francis
A novel series of 3-benzyl-substituted-4 (3 H)-quinazolinones were designed, synthesized
and evaluated for their in vitro antitumor activity. The results of this study demonstrated that 2 …
and evaluated for their in vitro antitumor activity. The results of this study demonstrated that 2 …
Biological activity evaluation and structure–activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer
W Li, N Li, Y Tang, B Li, L Liu, X Zhang, H Fu… - Bioorganic & Medicinal …, 2012 - Elsevier
The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid
(CA) were assessed by a high-throughout screening (HTS) method, and the structure …
(CA) were assessed by a high-throughout screening (HTS) method, and the structure …
Docking-based strategy to design novel flavone-based arylamides as potent V600E-BRAF inhibitors with prediction of their drug-likeness and ADMET properties
Abstract Background V600E-BRAF protein target has much potential for scientific research
as therapeutic target due to its involvement in human melanoma cancer. In the current …
as therapeutic target due to its involvement in human melanoma cancer. In the current …