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Pulmonary hypertension (PH) encompasses a syndrome of diseases that are characterized
by elevated pulmonary artery pressure and pulmonary vascular remodeling and that …

Autophagy is a self-digestion process that degrades intracellular structures in response to
stresses leading to cell survival. When autophagy is prolonged, this could lead to cell death …

Inhibition of angiogenesis is an important new modality for cancer treatment. 2-
methoxyestradiol (2ME2) is a novel antitumor and antiangiogenic agent, currently in clinical …

Sensing and responding to fluxes in oxygen tension is perhaps the single most important
variable in physiology, and animal tissues have developed a number of essential …

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and
therefore has a pivotal role in regulating the formation of biologically active steroids. The …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Methoxyestradiol (2-ME), a new anticancer agent currently in clinical trials, has been
demonstrated to inhibit superoxide dismutase (SOD) and to induce apoptosis in leukemia …

Estrogens occurring naturally in the body are metabolized to catecholestrogens (2‐and 4‐
hydroxyestradiol) by the cytochrome P450 enzymes. 2‐Hydroxy catecholestrogens are …