CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

The immense majority of genes are alternatively spliced and there are many isoforms
specifically associated with cancer progression and metastasis. The splicing pattern of …

Although changes in alternative splicing have been observed in cancer, their functional
contributions still remain largely unclear. Here we report that splice isoforms of the cancer …

CD44, a multi-structural and multifunctional transmembrane glycoprotein, was initially
identified as a receptor for hyaluronan that participates in both physiological and …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal
development and contributes to tissue and whole-body homeostasis, but can also promote …

It is generally thought that splicing factors regulate alternative splicing through binding to
RNA consensus sequences. In addition to these linear motifs, RNA secondary structure is …

Tumor metastasis remains the major cause of cancer-related death, but its molecular basis
is still not well understood. Here we uncovered a splicing-mediated pathway that is essential …

Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal
transition (EMT) and tumor metastasis. However, the scope of splicing factors that govern …