Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …

Recent evidence points to the gut microbiota as a regulator of brain and behavior, although
it remains to be determined if gut bacteria play a role in chronic pain. The endocannabinoid …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …

Background and Purpose Palmitoylethanolamide (PEA) is an endogenous congener of
anandamide and potentiates its actions at cannabinoid CB 1 and CB 2 receptors, and at …

The existence of acylethanolamides (AEs) in the mammalian brain has been known for
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …

Endophytic fungi are a well‐established reservoir of bioactive compounds that are
pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The …