[HTML][HTML] Immunogenic cell death inducer peptides: A new approach for cancer therapy, current status and future perspectives

H Aria, M Rezaei - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Immunogenic Cell Death (ICD) is a type of cell death that kills tumor cells by
stimulating the adaptive immune response against other tumor cells. ICD depends on the …

Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate

H Abbas, DK Derkaoui, L Jeammet, E Adicéam… - Biomolecules, 2024 - mdpi.com
Apoptosis, or programmed cell death, is a fundamental process that maintains tissue
homeostasis, eliminates damaged or infected cells, and plays a crucial role in various …

The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death

Y Matsuzawa-Ishimoto, X Yao, A Koide… - Nature, 2022 - nature.com
Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial
barrier and is associated with Crohn's disease, a major type of inflammatory bowel …

A cell-penetrating peptide targeting AAC-11 specifically induces cancer cells death

L Jagot-Lacoussiere, E Kotula, BO Villoutreix… - Cancer research, 2016 - AACR
AAC-11 is an antiapoptotic protein that is upregulated in most cancer cells. Increased
expression of AAC-11 confers a survival advantage when cancer cells are challenged with …

Regulation of mRNA export through API5 and nuclear FGF2 interaction

SM Bong, SH Bae, B Song, HR Gwak… - Nucleic acids …, 2020 - academic.oup.com
Abstract API5 (AP optosis I nhibitor 5) and nuclear FGF2 (F ibroblast G rowth F actor 2) are
upregulated in various human cancers and are correlated with poor prognosis. Although …

Validation of AAC-11-derived peptide anti-tumor activity in a single graft sezary patient-derived xenograft mouse model

J Habault, N Thonnart, C Ram-Wolff, M Bagot… - Cells, 2022 - mdpi.com
Sézary syndrome (SS) is an aggressive cutaneous T cell lymphoma with poor prognosis
mainly characterized by the expansion of a tumor CD4+ T cell clone in both skin and blood …

Killing of Plasmodium Sporozoites by Basic Amphipathic α-Helical Fusion Peptides

MC Aguirre-Botero, E Aliprandini, A Gladston, O Pacios… - Microorganisms, 2024 - mdpi.com
Membranolytic molecules constitute the first line of innate immune defense against
pathogenic microorganisms. Plasmodium sporozoites are potentially exposed to these …

Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication

AK Mayank, S Sharma, H Nailwal, SK Lal - Cell death & disease, 2015 - nature.com
Apoptosis of host cells profoundly influences virus propagation and dissemination, events
that are integral to influenza A virus (IAV) pathogenesis. The trigger for activation of …

Apoptosis inhibitor 5 is an endogenous inhibitor of caspase‐2

G Imre, J Berthelet, J Heering, S Kehrloesser… - EMBO …, 2017 - embopress.org
Caspases are key enzymes responsible for mediating apoptotic cell death. Across species,
caspase‐2 is the most conserved caspase and stands out due to unique features. Apart from …

Protective Effects of Polydatin from Grapes and Reynoutria japonica Houtt. on Damaged Macrophages Treated with Acetaminophen

C Liu, W Wang, K Zhang, Q Liu, T Ma, L Tan, L Ma - Nutrients, 2022 - mdpi.com
The unregulated use of acetaminophen (APAP), an antipyretic and analgesic drug, harms
hepatocytes and kidney cells, leading to liver failure and acute kidney injury. Herein, we …