One crucial barrier to progress in the treatment of cancer has been the inability to control the
balance between cell proliferation and apoptosis: enter ceramide. Discoveries over the past …

Much has been made about JLW Thudichum's colorful, and one could say clairvoyant,
naming of sphingosine “in commemoration of the many enigmas which it presented to the …

Receptor‐mediated drug delivery presents an opportunity to enhance therapeutic efficiency
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …

Background & Aims Ceramide, a sphingolipid metabolite, affects T-cell signaling, induces
apoptosis of cancer cells, and slows tumor growth in mice. However, it has not been used as …

Exosomes are secreted extracellular vesicles (EVs) that carry micro RNAs and other factors
to reprogram cancer cells and tissues affected by cancer. Exosomes are exchanged …

Most hepatocellular carcinoma (HCC) therapies fail to target cancer stem cells (CSCs) and
monitor cancer progression or regression. The purpose of this study was to evaluate the …

Non-alcoholic fatty liver disease (NAFLD), as one of the main causes of chronic liver disease
worldwide, encompasses a spectrum of liver conditions that are not caused by other …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

Hepatocellular carcinoma (HCC) is an aggressive and widespread cancer. Patients with
liver cirrhosis of different aetiologies are at a risk to develop HCC. It is important to know that …

Multidrug resistance (MDR) is associated with a wide range of pathological changes at
different cellular and intracellular levels. Nanoparticles (NPs) have been extensively …