Immune evasion is a key strategy adopted by tumor cells to escape the immune system
while promoting their survival and metastatic spreading. Indeed, several mechanisms have …

BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult
cancers, and this success has prompted the exploration of ICI therapy even in childhood …

Simple Summary Precision medicine is a revolutionary new way to deliver cancer treatment
by targeting specific genetic changes of the cancer of the individual child with the goal of …

Due to the growing number of young patients at risk of germ cell loss, there is a need to
preserve spermatogonial stem cells for patients who are not able to bank spermatozoa …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Over the past decade, there has been sustained research activity on programmed death-
1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors for breast cancer …

Purpose Childhood cancer survivorship care is a complex specialty, though it is increasingly
being integrated into the general practitioner's (GP) remit. Establishing the essential …

Ongoing rapid advances in molecular diagnostics, precision imaging, and development of
targeted therapies have resulted in a constantly evolving landscape for treatment of pediatric …

Rhabdoid tumors (RTs) of the brain (atypical teratoid/rhabdoid tumor; AT/RT) and
extracranial sites (most often the kidney; RTK) are malignant tumors predominantly …