The present investigation is aimed at systematically analyzing the recent literature about the
innovative scaffold involved in the reconstructive surgeries by applying growth factors and …

Abstract Platelet-rich fibrin (PRF), as an autologous blood preparation, has been receiving
increasing attention in recent years and has been successfully applied in various clinical …

Calcium phosphate cements (CPC) are currently widely used bone replacement materials
with excellent bioactivity, but have considerable disadvantages like slow degradation. For …

Bone defects of critical size after compound fractures, infections, or tumor resections are a
challenge in treatment. Particularly, this applies to bone defects in patients with impaired …

The use of biomaterials and implants for joint replacement, fracture fixation, spinal
stabilization and other orthopedic indications has revolutionized patient care by reliably …

To develop cost-effective and efficient bone substitutes for improved regeneration of bone
defects, heparin-modified mineralized collagen scaffolds were functionalized with …

Women's fertility is characterized both quantitatively and qualitatively mainly by the pool of
ovarian follicles. Monthly, gonadotropins cause an intense multiplication of granulosa cells …

Critical bone defects are the result of traumatic, infection-or tumor-induced segmental bone
loss and represent a therapeutic problem that has not been solved by current reconstructive …

Synergistic promotion of angiogenesis and osteogenesis in bone tissue-engineered
constructs remains a crucial clinical challenge, which might be overcome by simultaneous …

Mesenchymal stem cells (MSCs) are an important class of stem cells that can differentiate
into osteoblasts, chondrocytes, and adipocytes. MSCs must express CD105, CD73, and …