SUMMARY The Frank–Starling law of the heart applies to all classes of vertebrates. It
describes how stretch of cardiac muscle, up to an optimum length, increases contractility …

Thermal acclimation causes the heart of some fish species to undergo significant
remodelling. This includes changes in electrical activity, energy utilization and structural …

The determinants of relaxation in cardiac muscle are poorly understood, yet compromised
relaxation accompanies various pathologies and impaired pump function. In this study, we …

Cardiac troponin C belongs to the EF-hand superfamily of calcium-binding proteins and
plays an essential role in the regulation of muscle contraction and relaxation. To follow …

Publisher Summary Marine life in the polar, especially Antarctic, cold is characterized by a
low to moderate pace at permanently low temperatures. This chapter discusses the special …

Controversy abounds in the cardiac muscle literature over the rate-limiting steps of cardiac
muscle contraction and relaxation. However, the idea of a single biochemical mechanism …

Calcium Binding Proteins explains the unique and highly diverse functions of calcium in
biology, which are realized by calcium binding proteins. The structures and physical …

The cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial
hypertrophic cardiomyopathy. We previously showed that L29, together with neighboring …

Cardiac muscle thin filaments are composed of actin, tropomyosin, and troponin that change
conformation in response to Ca 2+ binding, triggering muscle contraction. Human cardiac …

The cardiac-specific N-terminus of cardiac troponin I (cTnI) is known to modulate the activity
of troponin upon phosphorylation with protein kinase A (PKA) by decreasing its Ca2+ affinity …