Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular
hemoglobin (Hb) has been found to trigger specific pathophysiologies that are associated …

The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …

Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high
mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and …

Control of blood vessel tone is central to vascular homeostasis. Here we show that
metabolism of tryptophan to kynurenine by indoleamine 2, 3-dioxygenase (Ido) expressed in …

This review presents evidence for two overlapping yet distinctive clinical types of sickle cell
disease. The basis of one is the vaso-occlusive crisis; the other is the consequence of …

Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-
1 (HO-1, encoded by Hmox1) prevents the development of experimental cerebral malaria …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …