Measurements of cardiac conduction velocity provide valuable functional and structural
insight into the initiation and perpetuation of cardiac arrhythmias, in both a clinical and …

We have previously developed a canine in vivo model of the long QT syndrome (LQTS)
using the neurotoxin anthopleurin A (AP-A), which acts by slowing sodium channel …

Background The long-QT syndrome (LQTS) is an electrophysiological (EP) entity
characterized by prolongation of cardiac repolarization and the occurrence of polymorphic …

Background—Catheter ablation of ventricular tachycardia (VT) is still one of the most
challenging procedures in cardiac electrophysiology, limited, in part, by unmappable …

Monomorphic ventricular tachycardias associated with regions of scar are most commonly
due to reentry. Catheter based techniques have recently been described for mapping of …

Introduction: Advancing age is an independent risk factor for atrial fibrillation (AF), which is
considered to be initiated by ectopic triggers and maintained by an arrhythmogenic …

Tachycardia-dependent QT/T alternans occurs in patients with the congenital or idiopathic
form of long-QT syndrome (LQTS) and may presage the onset of polymorphic ventricular …

Aims Cardiac optical mapping is the gold standard for measuring complex electrophysiology
in ex vivo heart preparations. However, new methods for optical mapping in vivo have been …

Background—Endocardial mapping is mandatory before radiofrequency catheter ablation
(RFCA). Mapping can be performed with either unipolar or bipolar recordings. Impact of the …

A growing area in the field of tissue engineering is the development of tissue equivalents as
model systems for in vitro experimentation and high-throughput screening applications …