Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Bacterial CRISPR systems provide acquired immunity against invading nucleic acids by
activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound …

Protein secretion in eukaryotes and prokaryotes involves a universally conserved protein
translocation channel formed by the Sec61 complex. Unrelated small-molecule natural …

Buruli ulcer is a neglected tropical disease caused by Myocobacterium ulcerans; it manifests
as a skin lesion, nodule, or ulcer that can be extensive and disabling. To assess the global …

The heterotrimeric Sec61 protein complex forms the functional core of the so-called
translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary …

The prospect of ever increasing antibiotic resistance eroding currently available treatment
options for bacterial infections underscores the need to continue to identify new antibiotics …

Buruli ulcer is an emerging chronic infectious skin disease caused by Mycobacterium
ulcerans. Mycolactone, an exotoxin produced by the bacterium, is the only identified …

Buruli ulcer is a neglected tropical disease that is characterized by non-fatal lesion
development. The causative agent is Mycobacterium ulcerans (M. ulcerans). There are no …