Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

The birth, evolution and death of metabolic gene clusters in fungi

A Rokas, JH Wisecaver, AL Lind - Nature Reviews Microbiology, 2018 - nature.com
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways
involved in ecologically specialized or accessory functions. Genes in these pathways are …

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

AL Lind, JH Wisecaver, C Lameiras, P Wiemann… - PLoS …, 2017 - journals.plos.org
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for
defense, virulence, and communication. The metabolic pathways that produce SMs are …

Secondary metabolism in Trichoderma – a genomic perspective

PK Mukherjee, BA Horwitz, CM Kenerley - Microbiology, 2012 - microbiologyresearch.org
Trichoderma spp. are a rich source of secondary metabolites (SMs). The recent publication
of the genome sequences of three Trichoderma spp. has revealed a vast repertoire of genes …

Comparative transcriptomics reveals different strategies of Trichodermamycoparasitism

L Atanasova, SL Crom, S Gruber, F Coulpier… - BMC genomics, 2013 - Springer
Background Trichoderma is a genus of mycotrophic filamentous fungi (teleomorph
Hypocrea) which possess a bright variety of biotrophic and saprotrophic lifestyles. The ability …

Biosynthetic gene clusters and the evolution of fungal chemodiversity

A Rokas, ME Mead, JL Steenwyk, HA Raja… - Natural product …, 2020 - pubs.rsc.org
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …

Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

A Osbourn - Trends in genetics, 2010 - cell.com
Microbes and plants produce a huge array of secondary metabolites that have important
ecological functions. These molecules have long been exploited in medicine as antibiotics …

A two-locus DNA sequence database for typing plant and human pathogens within the Fusarium oxysporum species complex

K O'Donnell, C Gueidan, S Sink, PR Johnston… - Fungal Genetics and …, 2009 - Elsevier
We constructed a two-locus database, comprising partial translation elongation factor (EF-
1α) gene sequences and nearly full-length sequences of the nuclear ribosomal intergenic …

The evolution of fungal metabolic pathways

JH Wisecaver, JC Slot, A Rokas - PLoS genetics, 2014 - journals.plos.org
Fungi contain a remarkable range of metabolic pathways, sometimes encoded by gene
clusters, enabling them to digest most organic matter and synthesize an array of potent small …

Disulfide-and multisulfide-containing metabolites from marine organisms

CS Jiang, WEG Müller, HC Schröder… - Chemical …, 2012 - ACS Publications
The special living environment in the oceans, including high concentration of salts, high
pressure, low concentration of oxygen, and dark conditions, has made marine organisms …