Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …

Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …

Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor,
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic
cancer subpopulation with stem cell properties have been increasingly recognized as potent …

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

Background Pancreatic cancer, one of the top two most fatal cancers, is characterized by a
desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and …

Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM
subtype was reported to be the most malignant, presenting severe hypoxia and necrosis …