Targeting hypoxic tumor microenvironment in pancreatic cancer
J Tao, G Yang, W Zhou, J Qiu, G Chen, W Luo… - Journal of hematology & …, 2021 - Springer
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …
Drug resistance driven by cancer stem cells and their niche
M Prieto-Vila, R Takahashi, W Usuba… - International journal of …, 2017 - mdpi.com
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
D Osuna de la Peña, SMD Trabulo, E Collin… - Nature …, 2021 - nature.com
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
Triple-negative breast cancer: current understanding and future therapeutic breakthrough targeting cancer stemness
KL Lee, YC Kuo, YS Ho, YH Huang - Cancers, 2019 - mdpi.com
Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …
receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor …
Triptolide and its derivatives as cancer therapies
P Noel, DD Von Hoff, AK Saluja, M Velagapudi… - Trends in …, 2019 - cell.com
Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor,
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …
Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
H Rezayatmand, M Razmkhah… - Stem cell research & …, 2022 - Springer
Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
P Zhou, B Li, F Liu, M Zhang, Q Wang, Y Liu, Y Yao… - Molecular cancer, 2017 - Springer
The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic
cancer subpopulation with stem cell properties have been increasingly recognized as potent …
cancer subpopulation with stem cell properties have been increasingly recognized as potent …
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
D Pradella, C Naro, C Sette, C Ghigna - Molecular cancer, 2017 - Springer
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …
Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in …
H Li, X Wang, C Wen, Z Huo, W Wang, Q Zhan… - Molecular cancer, 2017 - Springer
Background Pancreatic cancer, one of the top two most fatal cancers, is characterized by a
desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and …
desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and …
[HTML][HTML] Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis
JV Joseph, S Conroy, K Pavlov, P Sontakke, T Tomar… - Cancer letters, 2015 - Elsevier
Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM
subtype was reported to be the most malignant, presenting severe hypoxia and necrosis …
subtype was reported to be the most malignant, presenting severe hypoxia and necrosis …