Simple Summary The metabolic conversion of resources into living structures and processes
is fundamental to all living systems. The rate of metabolism ('fire of life') is critical for …

Decline of cellular functions especially cognitive is a major deficit that arises with age in
humans. Harnessing the strengths of small and genetic tractable model systems has …

Background Little is known about the role of amino acids in cellular signaling pathways,
especially as it pertains to pathways that regulate the rate of aging. However, it has been …

Abstract Background Many Caenorhabditis elegans mutations increase longevity and much
evidence suggests that they do so at least partly via changes in metabolism. However, up …

The nematode Caenorhabditis elegans is widely used as a model organism in many areas
of the life sciences. Metabolite profiling (metabolomics/metabonomics) is a powerful means …

To expand the understanding of aging in the model organism Caenorhabditis elegans,
global quantification of metabolite and protein levels in young and aged nematodes was …

Background and aims SKN-1, a C. elegans transcription factor analogous to the mammalian
NF-E2-related factor (Nrf2), has been known to promote oxidative stress resistance aiding …

Many mutations and allelic variants are known that influence the rate at which animals age,
but when in life do such variants diverge from normal patterns of aging? Is this divergence …

A properly functioning organism must maintain metabolic homeostasis. Deleterious
mutations degrade organismal function, presumably at least in part via effects on metabolic …

Changes in intermediary metabolism have profound effects on many aspects of C. elegans
biology including growth, development and behavior. However, many traditional …