Non-excitatory amino acids, melatonin, and free radicals: examining the role in stroke and aging

VJ Carretero, E Ramos, P Segura-Chama… - Antioxidants, 2023 - mdpi.com
The aim of this review is to explore the relationship between melatonin, free radicals, and
non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered …

Melatonin treatment in kidney diseases

M Markowska, S Niemczyk, K Romejko - Cells, 2023 - mdpi.com
Melatonin is a neurohormone that is mainly secreted by the pineal gland. It coordinates the
work of the superior biological clock and consequently affects many processes in the human …

Anti-inflammatory effects of melatonin in rats with induced type 2 diabetes mellitus

H Yapislar, E Haciosmanoglu, T Sarioglu… - Life, 2022 - mdpi.com
Introduction: Insulin resistance is associated with a pro-inflammatory state increasing the risk
for complications in patients with type 2 diabetes mellitus (T2DM). In addition to its …

Benefits of the neurogenic potential of melatonin for treating neurological and neuropsychiatric disorders

Y Potes, C Cachán-Vega, E Antuña… - International Journal of …, 2023 - mdpi.com
There are several neurological diseases under which processes related to adult brain
neurogenesis, such cell proliferation, neural differentiation and neuronal maturation, are …

Melatonin ameliorates diabetic hyperglycaemia-induced impairment of Leydig cell steroidogenic function through activation of SIRT1 pathway

P Wang, S Zhang, S Lin, Z Lv - Reproductive Biology and Endocrinology, 2022 - Springer
Background Diabetes mellitus (DM)-related complications are important health problems
worldwide. The underlying mechanisms for diabetic male subfertility/infertility are …

A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets

R Patel, N Parmar, N Rathwa, SP Palit, Y Li… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autoimmune-led challenge resulting in β-cell loss is responsible for the development of type
1 diabetes (T1D). Melatonin, a pineal hormone or sitagliptin, a dipeptidyl peptidase IV (DPP …

Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic …

JY Shim, JO Chung, D Jung, PS Kang, SY Park… - PloS one, 2023 - journals.plos.org
Diabetes mellitus (DM) is one of the most researched metabolic diseases worldwide. It leads
to extensive complications such as cardiovascular disease, nephropathy, retinopathy, and …

Hepatic encephalopathy and melatonin

A Arjunan, DK Sah, YD Jung, J Song - Antioxidants, 2022 - mdpi.com
Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic
hepatic disorders. HE is also a pernicious neuropsychiatric complication associated with …

Melatonin attenuates cellular senescence and apoptosis in diabetic nephropathy by regulating STAT3 phosphorylation

X Fang, W Huang, Q Sun, Y Zhao, R Sun, F Liu… - Life Sciences, 2023 - Elsevier
Aims Melatonin is an endogenous hormone related to the regulation of biorhythm. Previous
researchers have found that melatonin can ameliorate diabetic nephropathy (DN), but the …

[HTML][HTML] Effects of melatonin on glycemic variability in type 2 diabetes mellitus: Protocol for a crossover, double-blind, placebo-controlled trial

W Martorina, A Tavares - JMIR research protocols, 2023 - researchprotocols.org
Background: Glycemic variability is recognized as a significant factor contributing to the
development of micro-and macrovascular complications in individuals with type 2 diabetes …