Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

In supramolecular materials, molecular building blocks are designed to interact with one
another via non‐covalent interactions in order to create function. This offers the opportunity …

Novel indazole and benzimidazole analogues were designed and synthesized as tubulin
inhibitors with potent antiproliferative activities. Among them, compound 12b exhibited the …

Life is a dissipative nonequilibrium structure that requires constant consumption of energy to
sustain itself. How such an unstable state could have selected from an abiotic pool of …

This article is part of a Minifocus on microtubule dynamics. For further reading, please see
related articles:'Kinesins at a glance'by Sharyn A. Endow et al.,(J. Cell Sci. 123, pp. 3420 …

Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents,
and this is attributed to their ability to target MT dynamics and interfere with critical cellular …

Microtubules are dynamic polymers of tubulin subunits that underpin many essential cellular
processes, such as cell division and migration. Spermatogenesis is the process by which …

The variety of shapes and sizes of the microtubule cytoskeleton is as great as the number of
different cell types. This large variety is a consequence of the dynamic properties of …

The atomic structure of tubulin in a polymerized, straight protofilament is clearly distinct from
that in a curved conformation bound to a cellular depolymerizer. The nucleotide contents are …

We studied the role of a class II histone deacetylase, HDAC6, known to function as a potent
α-tubulin deacetylase, in the regulation of microtubule dynamics. Treatment of cells with the …