Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Animal behavior was classically considered to be determined exclusively by neuronal
activity, whereas surrounding glial cells such as astrocytes played only supportive roles …

Evidence demonstrates that chronic caffeine exposure, primarily through consumption of
coffee or tea, leads to increased alertness and anxiety. Preclinical and clinical studies …

Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

While the immune system is essential for survival, an excessive or prolonged inflammatory
response, such as that resulting from sustained heavy alcohol use, can damage the host …

Background The plenary session at the 2016 Behavior, Biology and Chemistry:
Translational Research in Addiction Conference focused on glia as potential players in the …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

The purpose of this review is to present animal research models that can be used to screen
and/or repurpose medications for the treatment of alcohol abuse and dependence. The …

Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the
initiation and development of alcohol and drug dependence. Alcohol consumption induced …