The role of thiols in antioxidant systems
The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …
specialized and unique features that enable them to serve a variety of different functions in …
[HTML][HTML] An overview on the therapeutics of neglected infectious diseases—Leishmaniasis and Chagas diseases
K Chanda - Frontiers in Chemistry, 2021 - frontiersin.org
Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …
[HTML][HTML] A microbial transporter of the dietary antioxidant ergothioneine
DG Dumitrescu, EM Gordon, Y Kovalyova… - Cell, 2022 - cell.com
Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …
the maintenance of intracellular redox homeostasis. However, many host-associated …
[HTML][HTML] Current trends in the pharmacological management of Chagas disease
V Ribeiro, N Dias, T Paiva, L Hagström-Bex… - International Journal for …, 2020 - Elsevier
Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …
[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II
TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …
Peroxiredoxins
B Hofmann, HJ Hecht, L Flohé - 2002 - degruyter.com
Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …
principles, specificities and biological function. Peroxiredoxins are low efficiency …
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
RL Krauth-Siegel, MA Comini - … et Biophysica Acta (BBA)-General Subjects, 2008 - Elsevier
Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …
Chemotherapy of human African trypanosomiasis: current and future prospects
AH Fairlamb - Trends in parasitology, 2003 - cell.com
Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …
Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …
a considerable global challenge. Despite the huge number of people infected, NDs do not …
Molecular basis of antimony treatment in leishmaniasis
Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year.
It is caused by Leishmania species, which are human protozoan parasites of the …
It is caused by Leishmania species, which are human protozoan parasites of the …