The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Summary Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for
the maintenance of intracellular redox homeostasis. However, many host-associated …

Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

Trypanosomes and leishmania, the causative agents of several tropical diseases, possess a
unique redox metabolism which is based on trypanothione. The bis (glutathionyl) …

Three of the four currently approved drugs for the treatment of African trypanosomiasis
(sleeping sickness) were developed over 50 years ago. All of the current therapies are …

Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year.
It is caused by Leishmania species, which are human protozoan parasites of the …