Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR) pathway is one of the most important intracellular pathways involved in …

Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …

Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3-
OH of the inositol ring of phosphoinositides, and deregulation of this pathway has …

Abstract Phosphatidylinositol-3 kinase (PI3K) pathway is one of the most frequently activated
pathogenic signaling cascades in human malignancies. PI3K is genetically mutated or …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

It is well established that tumor-associated macrophages (TAM) found in most advanced
tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating …

Phosphatidylinositol 3-kinases (PI3Ks) are important therapeutic targets for the treatment of
cancer, thrombosis, and inflammatory and immune diseases. The four highly homologous …

Phosphoinositol 3-kinases (PI3Ks) γ and δ are key enzymes in hematopoietic cells and have
been seen as high-value targets for the treatment of diseases with inflammatory and …

Abstract Phosphatidylinositol 3‐kinase gamma (PI3Kγ) has been regarded as a promising
drug target for the treatment of advanced solid tumors, leukemia, lymphoma, and …