Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to
infect other humans. Latency requires multiple functions: maintaining the herpesvirus …

Herpes simplex viruses (HSV) can undergo a lytic infection in epithelial cells and a latent
infection in sensory neurons. During latency the virus persists until reactivation, which leads …

Herpes simplex virus type 1 (HSV-1; human herpesvirus 1) and varicella-zoster virus (VZV;
human herpesvirus 3) are human neurotropic alphaherpesviruses that cause lifelong …

Reversible methylation of histone tails serves as either a positive signal recognized by
transcriptional assemblies or a negative signal that result in repression,,,. Invading viral …

Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

Herpes simplex virus (HSV) reactivation from latent neuronal infection requires stimulation of
lytic gene expression from promoters associated with repressive heterochromatin. Various …

Like other alpha-herpesviruses, Herpes Simplex Virus Type 1 (HSV-1) possesses the ability
to establish latency in sensory ganglia as a non-integrated, nucleosome-associated …

Like their cellular host counterparts, many invading viral pathogens must contend with,
modulate, and utilize the host cell's chromatin machinery to promote efficient lytic infection or …

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a
lifelong latent infection in the human host. Following primary replication in mucosal epithelial …

The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central
importance to recurrent disease and transmission of infection, yet interactions between host …