Abstract Purpose of Review The global epidemic of youth-onset obesity is tightly linked to
the rising burden of cardiometabolic disease across the lifespan. While the link between …

Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …

In pediatric population with diabetes and obesity, insulin resistance (HOMA-IR) has been
associated with worsening vascular outcomes, however, the cumulative role of HOMA-IR …

Objective Elevated rates of gluconeogenesis are an early pathogenic feature of youth-onset
type 2 diabetes (Y-T2D), but targeted first-line therapies are suboptimal, especially in African …

Obesity, a global epidemic chronic metabolic disease, urgently demands novel therapies. As
an antimalarial drug, quinacrine has not been reported for its anti-obesity effect to our …

Type 2 diabetes mellitus is a complex and under-treated disorder closely intertwined with
obesity. Adolescents with severe obesity and type 2 diabetes have a more aggressive …

Purpose Noise exposure in the workplace has been linked to a number of health
consequences. Our objectives were to explore the relationship between occupational noise …

Background: Recognizing insulin resistance (IR) in children remains challenging due to
uncertain IRI-HOMA cut-offs and unclear recommendations for evaluating IR based on …

Objective. To explore the best treatment of obesity in middle and old age. Methods. 80
obese patients in our hospital from January 2020 to December 2021 were randomly divided …

Objective This study explored the efficacy of acupuncture and metformin in enhancing
insulin sensitivity among women with polycystic ovary syndrome (PCOS) and insulin …