[HTML][HTML] The protective effects of silymarin on ischemia-reperfusion injuries: A mechanistic review

V Akbari-Kordkheyli… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Ischemia-reperfusion injuries (IRI) occur in different clinical conditions such as stroke,
trauma, organ transplantation, and so on. Ischemia damages mainly arise from oxygen …

Sylimarin as hepatic protector and immunomodulator in Nile tilapia during Streptococcus agalactiae infection

MS Owatari, GFA Jesus, A Brum, SA Pereira… - Fish & shellfish …, 2018 - Elsevier
This study investigated the use of silymarin, an extract obtained from the milk thistle (Silybum
marianum) and its effects as a possible hepatoprotector in Nile tilapia (Oreochromis …

[HTML][HTML] Loading of hydrophobic drug silymarin in pluronic and reverse pluronic mixed micelles

S Garg, M Peeters, RK Mahajan, P Singla - Journal of Drug Delivery …, 2022 - Elsevier
In the presented work, pure pluronic and mixed micelles of normal pluronics (F108, F127,
P85 and P84) with reverse pluronic (10R5) have been studied to enhance the solubilization …

[HTML][HTML] Effects of synthetic silymarin-PLGA nanoparticles on M2 polarization and inflammatory cytokines in LPS-treated murine peritoneal macrophages

M Azadpour, MM Farajollahi… - Iranian Journal of …, 2021 - ncbi.nlm.nih.gov
Objective (s): Silymarin (SM) is a natural antioxidant compound with good anti-inflammatory
effects, but its poor water solubility restricts its usage. Today, nanomaterial compounds (such …

Milk thistle: a future potential anti-osteoporotic and fracture healing agent

N Farhana Mohd Fozi, M Mazlan… - Current Drug …, 2013 - ingentaconnect.com
Osteoporosis is a progressive disease of the skeleton characterised by bone fragility due to
a reduction in bone mass and possibly to alteration in bone architecture that lead to a …

Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

PA Abhilash, R Harikrishnan, M Indira - Toxicology and applied …, 2014 - Elsevier
Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and
intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a …

Silybum marianum ethanolic extract: in vitro effects on protoscolices of Echinococcus granulosus G1 strain with emphasis on other Iranian medicinal plants

A Taghipour, F Ghaffarifar, J Horton, A Dalimi… - Tropical Medicine and …, 2021 - Springer
Background Cystic echinococcosis (CE), is a parasitic zoonosis caused by Echinococcus
granulosus (E. granulosus) larvae in liver and lungs of both humans and animals. Surgical …

Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes

WT Wu, YR Chen, DH Lu, FS Senatov, KC Yang… - Journal of Orthopaedic …, 2021 - Springer
Background Silymarin (SMN), a polyphenolic flavonoid, is involved in multiple bioactive
functions including anti-inflammation. Pretreatment with SMN demonstrated …

[HTML][HTML] Evaluation of the neuroprotective effect of silymarin on acrylamide-induced neurotoxicity

S Mehri, Q Dadesh, J Tabeshpour… - Jundishapur Journal of …, 2016 - brieflands.com
Background: Neurotoxicity is one of the most recognized effects of acrylamide (ACR) in
humans and animals. Oxidative stress is an important mechanism in ACR-induced …

Comparative nephroprotective effects of silymarin, N-acetylcysteine, and thymoquinone against carbon tetrachloride-induced nephrotoxicity in rats

L Ustyol, K Demiroren, I Kandemir, R Erten, K Bulan… - 2017 - sid.ir
Background: Many pharmacological agents may lead to KIDNEY damage. Preventing
NEPHROTOXICITY reduces the risk of morbidity and mortality, as well as decreasing …