Alcoholic liver disease is the result of cascade events, which clinically first lead to alcoholic
fatty liver, and then mostly via alcoholic steatohepatitis or alcoholic hepatitis potentially to …

Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They
import more than 1,000 different proteins from the cytosol. It had been assumed that the …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

α-Synuclein, a protein implicated in the pathogenesis of Parkinson disease (PD), is thought
to affect mitochondrial functions, although the mechanisms of its action remain unclear. In …

Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

The chapter provides a review of the state of art of the oxidative phosphorylation system in
mammalian mitochondria. The sections of the paper deal with:(i) the respiratory chain as a …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Alzheimer's amyloid precursor protein 695 (APP) is a plasma membrane protein, which is
known to be the source of the toxic amyloid β (Aβ) peptide associated with the pathogenesis …

Due to the worldwide surge in obesity and type 2 diabetes, the increased incidence of
nonalcoholic fatty liver disease (NAFLD) is a major concern for the public health. Indeed …