Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …

One of the commonest and least well understood posttranslational modifications of proteins
is their glycosylation. Human glycoproteins are glycosylated with a bewilderingly …

Human induced pluripotent stem (iPS) cells have the potential to establish a new field of
promising regenerative medicine. Therefore, the safety and the efficiency of iPS-derived …

Farm animals and their products have a longstanding and successful history of providing
significant contributions to human nutrition, clothing, facilitation of labour, research …

Understanding the genetic structure of domestic species provides a window into the process
of domestication and motivates the design of studies aimed at making links between …

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disorder caused by
mutations in the dystrophin gene, with an incidence of 1 in 3500 in new male births. Mdx …

Transgenic animal bioreactors can produce therapeutic proteins with high value for
pharmaceutical use. In this paper, we compared different systems capable of producing …

Transgenic systems are widely used to study the cellular and molecular basis of human
neurodegenerative diseases. A wide variety of model organisms have been utilized …

Contents Experimental animals in biomedical research provide insights into disease
mechanisms and models for determining the efficacy and safety of new therapies and for …

Targeted genome editing of nonrodent mammalian species has provided the potential for
highly accurate interventions into gene function in humans and the generation of useful …