Piper species are aromatic plants used as spices in the kitchen, but their secondary
metabolites have also shown biological effects on human health. These plants are rich in …

Ethnopharmacological relevance Depression, one of the most common psychiatric
disorders, is the fourth leading cause of long-term disability worldwide. A series of causes …

Depression is a major mental disease that is ranked as the fourth leading cause of disability.
In order to avoid unwanted adverse reactions, as well as improve efficacy, current …

The present study analyzed the possible memory-enhancing and antioxidant proprieties of
the methanolic extract of Piper nigrum L. fruits (50 and 100 mg/kg, orally, for 21 days) in …

Piperine, the major alkaloid constituent of black pepper, has been reported to possess a
wide range of pharmacological effects on the central nervous system, including …

Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant,
anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and …

Spices are natural plant products enriched with the history of being used as herbal medicine
for prevention of diseases. India is also known as the 'Land of Spices'. Out of 109 spices …

Abstract Background Piper nigrum L.(Piperaceae) is employed in traditional medicine of
many countries as analgesic, antiinflammatory, anticonvulsant, antioxidant, antidepressant …

Previous studies in our laboratory have demonstrated that piperine produced antidepressant-
like action in various mouse models of behavioral despair. This study aimed to investigate …

Depression is a mental disorder characterized by low mood, lack of motivation, negative
cognitive outlook, and sleep problems. Suicide may occur in severe cases, although suicidal …