Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

Several chromatographic approaches have been established over the last decades for the
production of pharmaceutically relevant viruses. Due to the large size of these products …

Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …

Purification of very large and complex, enveloped viruses, such as measles virus is very
challenging, it must be performed in a closed system because the final product cannot be …

Oncolytic measles virus (MV) is a promising treatment for cancer but titers of up to 1011
infectious particles per dose are needed for therapeutic efficacy, which requires an efficient …

Purification of recombinant proteins is often a challenging matter because high purity and
high recovery are desired. If the expressed recombinant protein is also in a complex matrix …

The surfaces of the polyacrylamide cryogels were coated with L-tryptophan (cryogel-Trp) or
L-phenylalanine (cryogel-Phe) to enhance crude leaf extract-derived ora-pro-nobis (OPN) …

Since the earliest days, occurrence of deadly outbreaks caused by prevalence of different
pathogenic virus infections affected human community periodically and caused millions of …

Cancer therapy with oncolytic measles virus (MV) requires high titers of pure, infectious virus
particles (~ 108 times more particles per dose than the measles vaccine). A gentle but …

Options for hydrophobic-interaction chromatography (HIC) for purification of cell culture-
derived influenza A and B virus have been assessed using a 96-well plate format using a …