Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

There is growing appreciation of the role that the extracellular environment plays in
regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in …

Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation.
However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically …

The ability to replicate the 3D myocardial architecture found in human hearts is a grand
challenge. Here, the fabrication of aligned cardiac tissues via bioprinting anisotropic organ …

We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

Abstract 3D bioprinting is emerging as a promising technology for fabricating complex tissue
constructs with tailored biological components and mechanical properties. Recent advances …

Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …