Revolutionizing disease modeling: the emergence of organoids in cellular systems

R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Navigating environmental transitions: the role of phenotypic variation in bacterial responses

MR Spratt, K Lane - Mbio, 2022 - Am Soc Microbiol
The ability of bacteria to respond to changes in their environment is critical to their survival,
allowing them to withstand stress, form complex communities, and induce virulence …

Building a tissue: mesenchymal and epithelial cell spheroids mechanical properties at micro-and nanoscale

NV Kosheleva, YM Efremov, PI Koteneva, IV Ilina… - Acta Biomaterialia, 2023 - Elsevier
Cell transitions between the epithelial and mesenchymal phenotypes provide the regulated
morphogenesis and regeneration throughout the ontogenesis. The tissue mechanics and …

[HTML][HTML] Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling

Y Zheng, F Han, A Ho, Y Xue, Z Wu, X Chen… - Mucosal …, 2023 - Elsevier
Mucosa-associated invariant T (MAIT) cells are the largest population of unconventional T
cells in humans. These antimicrobial T cells are poised with rapid effector responses …

3D multicellular systems in disease modelling: From organoids to organ-on-chip

C Goldrick, I Guri, G Herrera-Oropeza… - Frontiers in Cell and …, 2023 - frontiersin.org
Cell-cell interactions underlay organ formation and function during homeostasis. Changes in
communication between cells and their surrounding microenvironment are a feature of …

Mimicking the liver function in micro-patterned units: Challenges and perspectives in 3D bioprinting

Z Heydari, P Pooyan, P Bikmulina, A Pozdnyakov… - Bioprinting, 2022 - Elsevier
Abstract Bioprinting of 3-dimensional (3D) micro-patterned structures could be a promising
approach to mimic complex organs in vivo. This technique holds promise for generating …

New drug discovery

B Yingngam - Multidisciplinary Applications of Natural Science for …, 2023 - igi-global.com
The field of drug discovery is continually advancing with the emergence of new technologies
and scientific developments. Moreover, there is a recent growing interest in exploiting …

Advances in organoid technology for veterinary disease modeling

B Chen, RF Slocombe, SR Georgy - Frontiers in Veterinary Science, 2023 - frontiersin.org
Organoids are in vitro organ-like structures that faithfully recapitulate many characteristics of
a specific organ. During the past decades, major progress has been accomplished in …

In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models

L Mahieu, L Van Moll, L De Vooght… - FEMS Microbiology …, 2024 - academic.oup.com
Bacterial pneumonia greatly contributes to the disease burden and mortality of lower
respiratory tract infections among all age groups and risk profiles. Therefore, laboratory …

Application of stem cell-derived extracellular vesicles as an innovative theranostics in microbial diseases

H Keshavarz Alikhani, B Shokoohian… - Frontiers in …, 2021 - frontiersin.org
Extracellular vesicles (EVs), as nano-/micro-scale vehicles, are membranous particles
containing various cargoes including peptides, proteins, different types of RNAs and other …