Antipsychotic drugs are the mainstay in the treatment of schizophrenia. However, one-third
of patients do not show adequate improvement in positive symptoms with non-clozapine …

The underlying pathologies of psychiatric disorders, which cause substantial personal and
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …

The negative symptoms of schizophrenia, which often appear earlier than any other
symptom, are prominent and clinically relevant in the majority of patients. As a result, interest …

Background Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging
(MRI) technique that can measure the magnetic susceptibility of tissues, which can reflect …

Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common,
often refractory, neuropsychiatric conditions for which new treatment approaches are …

Purpose Major depressive disorder (MDD) is a common mood disorder. However, it still
remains challenging to select sensitive biomarkers and establish reliable diagnosis methods …

Background Behavioral symptoms, including mood disorders, substantially impact the
quality of life of patients with inflammatory bowel disease (IBD), even when clinical …

Our brain can be recognized as a network of largely hierarchically organized neural circuits
that operate to control specific functions, but when acting in parallel, enable the performance …

Early studies posited a relationship between sleep and the basal ganglia, but this
relationship has received little attention recently. It is timely to revisit this relationship, given …

Psychiatric disorders are highly prevalent and display considerable clinical and genetic
overlap. Dopaminergic and serotonergic neurotransmission have been shown to play an …