Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

Background All molecules, structures, cells in organisms are subjected to destruction during
the process of vital activities. In the organisms of most multicellular animals and humans, the …

Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

Cryo-electron tomography (cryo-ET) has become a powerful approach to study the high-
resolution structure of cellular macromolecular machines in situ. However, the current …

In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …

Over the course of evolution, the centrosome function has been conserved in most
eukaryotes, but its core architecture has evolved differently in some clades, with the …

Centrioles are microtubule-based structures crucial for forming flagella, cilia and
centrosomes. Through these roles, centrioles are critical notably for proper cell motility …

Centriole duplication is a high-fidelity process driven by Polo-like kinase 4 (Plk4) and a few
conserved initiators. Dissecting how Plk4 and its receptors organize within centrosomes is …

Microtubules play important roles in biological functions by forming superstructures, such as
doublets and branched structures, in vivo. Despite the importance, it is challenging to …

Centriole biogenesis, as in most organelle assemblies, involves the sequential recruitment
of sub-structural elements that will support its function. To uncover this process, we …