Peptides, peptidomimetics, and carbohydrate–peptide conjugates as amyloidogenic aggregation inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for 60–
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …
80% of dementia cases. For many years, AD causality was attributed to amyloid-β (Aβ) …
Systematic computational strategies for identifying protein targets and lead discovery
Computational algorithms and tools have retrenched the drug discovery and development
timeline. The applicability of computational approaches has gained immense relevance …
timeline. The applicability of computational approaches has gained immense relevance …
Polyphenols in combination with β-cyclodextrin can inhibit and disaggregate α-synuclein amyloids under cell mimicking conditions: A promising therapeutic alternative
Parkinson's disease is characterized by the presence of insoluble and neurotoxic
aggregates (amyloid fibrils) of an intrinsically disordered protein α-synuclein. In this study we …
aggregates (amyloid fibrils) of an intrinsically disordered protein α-synuclein. In this study we …
Molecular insights into the critical role of gallate moiety of green tea catechins in modulating prion fibrillation, cellular internalization, and neuronal toxicity
N Admane, A Srivastava, S Jamal, R Sharma… - International Journal of …, 2022 - Elsevier
Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal
neurodegenerative diseases with no approved therapeutics. TSE pathology is characterized …
neurodegenerative diseases with no approved therapeutics. TSE pathology is characterized …
First examples of bispidine-ferrocene cyclophanes
AV Medved'ko, DP Krut'ko, SV Gaisen… - Journal of …, 2021 - Elsevier
Two approaches for the syntheses of bispidine-ferrocene cyclophanes were reported. Both
include the acylation of 1, 5-dimethylbispidin-9-one (H 2 Bp) or its pendant amino-armed …
include the acylation of 1, 5-dimethylbispidin-9-one (H 2 Bp) or its pendant amino-armed …
The gelsolin pathogenic D187N mutant exhibits altered conformational stability and forms amyloidogenic oligomers
Gelsolin is an actin-severing protein that attains an open functional conformation in the
presence of Ca2+ or low pH. Mutations (D187N/Y) in the second domain of gelsolin trigger …
presence of Ca2+ or low pH. Mutations (D187N/Y) in the second domain of gelsolin trigger …
Prion protein transcription is auto-regulated through dynamic interactions with G-quadruplex motifs in its own promoter
Cellular prion protein (PrP) misfolds into an aberrant and infectious scrapie form (PrP Sc)
that lead to fatal transmissible spongiform encephalopathies (TSEs). Association of prions …
that lead to fatal transmissible spongiform encephalopathies (TSEs). Association of prions …
Identification and validation of l‐asparaginase as a potential metabolic target against Mycobacterium tuberculosis
Abstract Multidrug‐resistant Mycobacterium tuberculosis (Mtb) has emerged as a major
health challenge, necessitating the search for new molecular targets. A secretory …
health challenge, necessitating the search for new molecular targets. A secretory …
Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review
L Hellewell, NM Gilani, CJ Stanton… - Future Medicinal …, 2022 - Taylor & Francis
Aims: This systematic review was carried out to determine whether synthetic
peptidomimetics exhibit significant advantages over antimicrobial peptides in terms of in …
peptidomimetics exhibit significant advantages over antimicrobial peptides in terms of in …
The polyphenolic phytoalexin polydatin inhibits amyloid aggregation of recombinant human prion protein
Prion diseases involve misfolded and highly infectious aggregates of prion protein (PrPSc)
which forms amyloid plaques leading to fatal neurodegeneration. The absence of clinically …
which forms amyloid plaques leading to fatal neurodegeneration. The absence of clinically …